My plan to prevent or reverse coronary heart disease（我的终结冠心病方案）
1.My diea:
1.我的想法：
From biological symbiosis evolution environment, find a group of strains. These strains can secrete special enzymes, which are not only resistant to pepsin and trypsin, but also can be absorbed from the intestine into lymph and blood circulation. Then, these enzymes can directly dissolve embolism material, cure and reverse circulatory system embolism diseases and intercellular obstruction diseases, including coronary artery heart disease. Perhaps this way will become a new method of anti-aging.
从生物共生进化环境中找到一组菌株，这些菌株能分泌特殊的酶，这些酶不仅能抵抗
胃蛋白酶、
胰蛋白酶等，而且能被肠道吸收进入淋巴和血液循环，然后能直接溶解栓塞物质，进而治愈和逆转包括冠心病在内的循环系统栓塞性疾病和细胞间隙阻塞性疾病，这也许是抗衰老的新方法。
2. Differences between my idea and other existing schemes:
2.我的想法与现有其他方案的不同之处：
The use of oral absorption of exogenous enzymes directly degrade the obstructive protein and protein complex in human body.
利用外源酶的口服吸收直接降解人体内阻塞性蛋白及蛋白复合物。
3.My plan, targets and timelines
3.我的发展计划、阶段性目标和时间线：
The 1st 150 days: screening and identification of more than 10 microbial strains; The 2nd 150 days: fermentation, isolation, and purification of enzymes and biochemical identification; The 3rd 150 days: To test the enzymes oral metabolic characteristics (the rate of intestinal absorption); The 4th 150 days: To evaluate the safety and thrombolytic characteristics of enzymes with animal models; The 5th 150 days: Thrombolytic characteristics of the enzymes tested in health volunteers and clinical applications.
第一个150日：筛选和鉴定10个以上目标菌株；第二个150日：发酵、分离、纯化酶及生化鉴定；第三个150日：测试酶的口服代谢特性（肠道吸收率）；第四个150日：
动物模型测试酶的安全性和溶栓特性等；第五个150日：志愿者测试酶的溶栓特性及申请临床。
4. Key words:
4.我的想法的三个关键词：
biomimetic drugs;enzyme absorbed into blood from the gastrointestinal tract;enzymatic thrombolysis.
5. My particularity:
5.我所具备的特质：
As one of a brave thinker, I insist on long-term observation of nature life, thinking about symbiotic evolution, exploring for the Chinese traditional medicines and the biomimetic drugs. I am good at exploring microbial strains with the special pharmacological functions, oriented to special pharmacology thinking.
我是长期观察自然界生物生存、思考共生进化、发掘中医药及探索仿生药物的勇敢思想者，擅长于以药物学思维导向寻找发现特殊药理功能的微生物菌株。
6 .Specialties of my team and the division of labor:
6.我的团队需要的专业和分工：
The research team need zoological researchers in mollusk classification, arthropod classification, microbial researchers in microbial screening, isolation, fermentation, biochemical researchers in enzymatic and biochemical properties, pharmaceutical researchers in microbial and biochemical pharmacy, drug metabolism, medicine effect of drugs, and domestic and foreign intellectual property experts of patent application in microbial strains, drug application of strains, enzyme and gene, drug application of enzyme.
这个研究团队需要专业于软体动物分类、节肢动物分类等动物学研究者、专业于微生物筛选分离、发酵等微生物学研究者、专业于酶生化特性等生物化学研究者、专业于微生物与生化药学、药物代谢、药物效应等药学研究者及专业于菌株、菌株的药物应用、酶及基因、酶的药物应用等国内外专利申请的知识产权专家。
7. what kinds of organization and partnership I need:
7.我需要什么样的组织机构和合伙投资人：
The organization and the partnership of investors I need should be bio pharmaceutical companies or institutes, professional in microbial screening, fermentation optimization, enzyme separation and purification. The most preferred organization scheme can be venture capital investment in the new set up R & D team. And the project will be implemented by following most of the R & D outsourcing mode.
需要的组织机构和合伙投资人是专业于微生物筛选、发酵优化和酶分离纯化的生物医药公司或研究所等，最优选的组织方案可以是新组建研发团队加上风险投资，以大部分外包研发方式实施项目。
Author: Zhong-hui Shi
作者：施忠辉
Major and hobbies: Entomology, botany, microbiology and pharmacology.
专业及兴趣：昆虫学、植物学、微生态学和药物学。
Email:325066546@qq.com
网站：http://www.onebraveidea.com/
