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重金求助马西替坦 的原研的晶型专利及到期日?

求助马西替坦 的原研的晶型专利及到期日,一直没找见,万能的虫有,帮我解答下
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再次声明,原研上市产品,绝无晶型专利保护
而且后续亦无权保护,除非以析晶工艺的形式
山德士申请了一个晶型,国内三家申请新晶型。感觉原研晶型肯定有,可能还未进入中国。
1、原研上市产品,绝无晶型专利保护
2、原研迄今未申请晶型专利
我也是没查到他的晶型保护,很有可能没有保护,真是奇葩
有晶型I的,但是还没时间具体检索,
EMEA明确了其最稳定晶型:
Several polymorphic forms have been described including different solvates. All macitentan batches manufactured so far for clinical studie ...
你好 ,原研是否有晶型保护,请再帮我查一下
再次声明,原研上市产品,绝无晶型专利保护
1、原研上市产品,绝无晶型专利保护
2、原研迄今未申请晶型专利
山德士申请了一个晶型,国内三家申请新晶型。感觉原研晶型肯定有,可能还未进入中国。
那原研的晶型专利是申请了的咯
有晶型I的,但是还没时间具体检索,
EMEA明确了其最稳定晶型:
Several polymorphic forms have been described including different solvates. All macitentan batches manufactured so far for clinical studies and commercial purposes correspond to the same stable polymorphic form which is a true polymorph with a melting point of 135°C. It is the thermodynamically most stable form at room temperature. Long-term stability studies on several clinical and registration batches showed no polymorphic change of after up to 36 months of storage at 30 °C / 65% RH. Results of the dynamic vapour sorption of macitentan show that it is not hygroscopic.
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