盐酸普鲁卡因胺片 USP
第一法：Medium: 0.1 N hydrochloric acid; 900 mL.
Apparatus 2: 50 rpm.
Times: 1（30%~60%）, 4（60%~90%）, and 6 hours.（≥75%）
第二法：ACID STAGE: 0.1 N hydrochloric acid; 900 mL for 1 hour.
BUFFER STAGE: 0.05 M phosphate buffer, pH 7.5; 900 mL (see Buffer Solutions under Reagents, Indicators, and Solutions) for not less than 8 hours.
Apparatus 2: 50 rpm, with sinkers.
Times: 1（30%~60%）, 4（60%~90%）, and 8 hours（≥80%）.
第三法：Medium—Proceed as directed under Test 2.
Apparatus 2: 50 rpm, with sinkers.
Times: 1（25%~50%）, 3（40%~75%）, 6（65%~90%）, and 8 hours（≥80%）
第四法 Medium: 0.1 N hydrochloric acid; 900 mL.
Apparatus 1: 50 rpm.
Times: 1（≤30%）, 2（25%~45%）, 4（45%~75%）, 8（70%~90%）, and 14 hours（≥80%）.
第五法：Medium— Proceed as directed for Method B under Delayed Release Dosage Forms.
ACID STAGE: 0.1 N hydrochloric acid; 1000 mL for 1 hour.
BUFFER STAGE: 0.05 M phosphate buffer, pH 7.5; 1000 mL (see Buffer Solutions under Reagents, Indicators, and Solutions) for not less than 8 hours.
Apparatus 2: 50 rpm, with sinkers 500mg规格 Times: 1（30%~45%）, 4（55%~75%）, 6（≥65%）, and 8 hours.（≥75%）
750mg与1000mg规格片剂： Times: 1（30%~50%）, 4（60%~80%）, 6（70%~90%）, and 8 hours.（≥75%）
第六法：Medium—Proceed as directed for Test 2.
Apparatus 2: 50 rpm.
Times: 1, 4, and 8 hours.
规格不同，溶出标准也有不同
第七法：Medium— Proceed as directed for Method B under Delayed- Release Dosage Forms.
ACID STAGE: 0.1 N hydrochloric acid; 900 mL for 1 hour.
BUFFER STAGE: 0.05 M phosphate buffer, pH 7.5; 900 mL (see the Buffer Solutions under Reagents, Indicators, and Solutions) for not less than 8 hours.
Apparatus 2: 50 rpm, with sinkers. .
Times: 1, 4, 6, and 8 hours.
Procedure—Proceed as directed for Procedure in Test 1.
Tolerances—Proceed as directed for Tolerances in Test 2.
