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1,2-Ethanedithiol, also known as HSCH2CH2SH, is a chemical compound with a molecular formula of C2H6S2 and a molecular weight of 94.20. It is a commercially available reagent with a boiling point of 146°C and a density of 1.123 g/cm3 at 23°C. It is slightly soluble in water and easily miscible with organic solvents.
When 1,2-Ethanedithiol reacts with aldehydes, ketones, and acetaldehyde, it undergoes condensation reactions to form 1,3-dithiacyclopentane, which is used for carbonyl protection. It exhibits similar stability, condensation selectivity, and carbonyl regeneration conditions as 1,3-propanedithiol. It can be used to protect esters and lactones with enone dithioacetals and/or dithiolactone.
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