如何检测多肽原料药中每个氨基酸（残基）的光学纯度?

如果消旋，HPLC测出来不是双峰吗？
20-30肽中只有一个氨基酸消旋，HPLC估计也很难分离差向异构杂质。

Control Strategies for Synthetic Therapeutic Peptide APIs—Part I: Analytical Consideration

定性还好处理，定量确实是个难题，感觉量大测不准哈

Control strategies  for  synthetic  therapeutic  peptide  APIs  part  II—raw  material considerations

如果消旋，HPLC测出来不是双峰吗？

Control Strategies for Synthetic Therapeutic Peptide APIs—Part I: Analytical Consideration



Control Strategies for Synthetic Therapeutic Peptide APIs Part II: Raw Material Considerations

http://www.pharmtech.com/control ... rial-considerations

Control Strategies for Synthetic Therapeutic Peptide APIs Part III: Manufacturing Process Considerations

http://www.pharmtech.com/control ... cess-considerations

Mark，好奇这个问题的答案。