Naik, Mayuri M.; Tilve, Santosh G.; Kamat, Vijayendra P.
题目 5
To a solutionof acetophenone (1 mmol) in wet acetone (containing1percent w/w water) (20 mL/mmol) was added potassiumcarbonate (8 equiv.) and then pyridine (4 equiv.). Thesolution was stirred at 60°C for 15 min and aroylchloride (2 equiv.) was slowly added. The reactionmixture was stirred upon refluxing for 24–48 h. Aftercooling down to room temperature, acetone wasevaporated. Acetic acid (10percent) was added, the solutionwas stirred till it stopped bubbling. The residue wasfiltered off, washed with water (2×50 mL) to make itneutral, vacuum-dried, and then crystallized fromacetone (20 mL) to produce pure products. 2-Phenyl-4H-chromen-4-one (16a). Yield 83percent,mp 96–99°C
