TRAM-34是一种有效的、选择性的钾通道抑制剂？ ¹

TRAM-34是一种有效的、选择性的中电导Ca²⁺-activated K+channel(IKCa1，KCa3.1)抑制剂，具有高选择性和不抑制细胞色素P450的特点。与其他离子通道相比，TRAM-34的选择性高200到1500倍。在体外研究中，TRAM-34选择性抑制IKCa1而不会阻断细胞色素P450酶(CYP3A4)。TRAM-34还能有效抑制IKCa1转染的细胞中的IKCa1通道，以及人类T淋巴细胞和T84细胞中的IKCad电流。TRAM-34还能抑制人类T淋巴细胞的激活，对白血病细胞株的细胞学研究也具有潜力。此外，TRAM-34还能改善TGF-β1诱导的系膜细胞阻滞，减少细胞的早衰、表型转化和纤维样增生。

TRAM-34的应用领域

TRAM-34可用于白血病细胞株的细胞学研究。在对白血病细胞株HL-60的实验中，TRAM-34能够抑制细胞的增殖和侵袭能力，并诱导细胞凋亡和G0/G1期阻滞。此外，TRAM-34还能改善TGF-β1诱导的系膜细胞阻滞，减少细胞的早衰、表型转化和纤维样增生。研究结果表明，TRAM-34对于白血病细胞株的治疗具有潜在的临床应用价值。

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