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盐酸右美托咪定晶型的问题?

盐酸右美托咪定有没有原研晶型文献报告,有的话求文献,谢谢各位大佬了:cat39
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晶形未见原研的描述:不过在EMA的审评报告中提到过,本品存在两种晶形形式,无水物和一水合物,其中无水物被用作制成制剂。
It appears as an almost white, or white, crystalline powder that is freely soluble in water, chloroform,ethanol and methanol; slightly soluble in acetonitrile and practically soluble in ethe. Dexmedetomidinehas one chiral centre and is therefore optically active. During the synthesis only one (S)-enantiomer is manufactured and used in the manufacture of the finished product. There are two recognisedpolymorphic forms of dexmedetomidine: anhydrous (form A) and monohydrate (form B). Form A is consistently obtained during synthesis and is used in the manufacture of the finished product.
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