CD3抗体(APC)是一种多克隆抗体,可以特异性结合CD3抗体(APC),主要用于多种实验检测,如ICC/IF、Dotblot、ELISA、IHC-P、IHC-Fr、Immunomicroscopy和WB等。
抗原与抗体的特异性结合是基于它们之间的结构互补性和亲和性,这取决于它们的空间构型。除了分子构型的互补性外,抗原表位和抗体超变区必须密切接触才能产生足够的结合力。
CD3是T细胞的共受体,由四个不同的链组成,包括CD3γ链、CD3δ链和2个CD3ε链。它们与TCR和ζ-链一起构成T细胞受体复合物,用于产生激活信号。
APC基因是一个大的管家基因,含有8538 bp的开放式可读框架,共15个外显子。其中第15外显子是人类已知最大的外显子,编码2843个氨基酸。
CD3抗体(APC)在结直肠癌患者预后中的作用研究发现,癌巢内CD3+T细胞密度与患者的无病生存率和总生存率呈正相关。因此,癌巢内CD3+T细胞密度可能是结直肠癌预后的一个较好指标。
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