2-苯并唑啉酮;CAS号59-49-4;试剂级品牌：Solarbio 国产 -盖德化工网

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2-苯并唑啉酮;CAS号59-49-4;试剂级

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纯度：98 %

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货号：IB1320

品牌：Solarbio

CAS编号：59-49-4 查看相似产品

产地：国产

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更新时间2023-05-05

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CAS	59-49-4
中文名称	2-苯并唑啉酮
英文名称	2-Benzoxazolinone
别名	2-苯并恶唑酮
纯度	≥98%
分子式	C₇H₅NO₂
分子量	135.12
外观(性状)	Light brown to brown Solid
储存条件	Powder : -20℃, 2 years;In solvent(母液): -20℃, 1 month; -80℃, 6 months
溶解性	Soluble in DMSO
EC	EINECS 200-430-0
MDL	MFCD00005716
InChIKey	ASSKVPFEZFQQNQ-UHFFFAOYSA-N
InChI	InChI=1S/C7H5NO2/c9-7-8-5-3-1-2-4-6(5)10-7/h1-4H,(H,8,9)
PubChem CID	6043
SMILES	O=C1OC2=CC=CC=C2N1
描述	(It is an anti-leishmania reagent.)
靶点	Parasite
通路	Anti-infection
生物活性	2-Benzoxazolinone (BOA), a well-known allelochemical with strong phytotoxicity, is a potential herbicidal candidate.[1] 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[2]
IC50	LC50: 40 μg/mL (L. donovani)[2]
In Vitro	BOA induces oxidative stress in mung bean as indicated by increased generation of H2O2, enhanced LP and accumulation of endogenous PRO. It is accompanied by an upregulation of the activities of various scavenging enzymes—SODs, peroxidases, CATs and GR—in roots and leaves of mung bean in response to BOA exposure.[1] The LC50 values for BOA and pentamidine are 40 pg/ml and 39.8 pg/mi, respectively. BOA showed antileishmanial activity and compares well with pentamidine. [2]
激酶实验	For the BOA treatment, we followed the method used by Burgos and Talbert , wherein seeds germinated on a filter paper disc moistened with BOA and grow until the measurement of seedling length. Seeds of mung bean were surface sterilized with sodium hypochlorite (0.1%, w/v) followed by washing with distilled water three times. These were subjected to germination in 15 cm diameter Petri dishes lined with a Whatman no. 1 filter circle and moistened with 7 ml of respective BOA treatment solution or distilled water (control). The 7 ml of the 0.1, 0.5, 1.0, 2.5, and 5.0 mM BOA solution used cor_x005frespond to nearly 0.0946, 0.473, 0.946, 2.365, 4.73 mg ml–1 BOA, respectively. It was in the range similar to that used by Burgos and Talbert [13]. Twenty-five mung bean seeds were used in each Petri dish. Five replicates were maintained for each treatment in a completely randomized manner. All the Petri dishes were placed in a seed germinator maintained at 25 ± 2 °C, 75 ± 3% relative humidity and a 16 h:8 h light: dark photoperiod with a photosynthetic photon flux density of 150 μmol m–2 s–1. After 7 days, root and shoot length of emerged seedlings from each treatment were measured. Further, roots and leaves from each treatment were harvested and stored at –80 °C prior to enzyme extraction and other estimations.[1]
细胞实验	Promastigote para- sites in the stationary phase of growth (1 x io parasite/mi) were inoculated into culture tubes containing BHI-agar as solid part and HBSS as hquid part. To these tubes different concentrations (10 to 100 pg/mi, DMSO/PBS) of BOA and pentamidine were added, respectively. The inhibitory effect of BOA was compared with pentamidine which is known to be active against leishmaniasis, and with untreated control cultures. The whole operation was carried out aseptically in an ultraviolet chamber and the tubes were incubated for 5 days at 22 °C. The toxicity of DMSO was determined by adding different amounts of solvent (0.1 to 1.5%) to suspensions of promastigotes under the conditions described above. After five days the value of the non-toxic dilution was found to be 0.6% and growth inhibition (up to 15%) was observed between 0.6% and 1 %; therefore, higher concentrations of DMSO were never used. Antileishmanial activity of each of the com_x005fpounds was determined by counting the number of live parasites per field microscopically. The LC55 values were calculated by probit analysis and no mortallty was observed in mice when BOA was administered ((p.) in the doses ranging from 0.25—1 g/kg. The mice were kept under observation for one week.[2]
数据来源文献	[1] Batish D R , Singh H P , Setia N , et al. 2-Benzoxazolinone (BOA) induced oxidative stress, lipid peroxidation and changes in some antioxidant enzyme activities in mung bean (Phaseolus aureus).[J]. Plant Physiol Biochem, 2006, 44(11-12):819-827. [2]. Kapil A, et al. Leishmanicidal activity of 2-benzoxazolinone from Acanthus illicifolius in vitro. Planta Med. 1994 Apr;60(2):187-8.
规格	50mg 100mg 250mg
单位	瓶

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CAS59-49-4

CAS	59-49-4
中文名称	2-苯并唑啉酮
英文名称	2-Benzoxazolinone
别名	2-苯并恶唑酮
纯度	≥98%
分子式	C₇H₅NO₂
分子量	135.12
外观(性状)	Light brown to brown Solid
储存条件	Powder : -20℃, 2 years;In solvent(母液): -20℃, 1 month; -80℃, 6 months
溶解性	Soluble in DMSO
EC	EINECS 200-430-0
MDL	MFCD00005716
InChIKey	ASSKVPFEZFQQNQ-UHFFFAOYSA-N
InChI	InChI=1S/C7H5NO2/c9-7-8-5-3-1-2-4-6(5)10-7/h1-4H,(H,8,9)
PubChem CID	6043
SMILES	O=C1OC2=CC=CC=C2N1
描述	(It is an anti-leishmania reagent.)
靶点	Parasite
通路	Anti-infection
生物活性	2-Benzoxazolinone (BOA), a well-known allelochemical with strong phytotoxicity, is a potential herbicidal candidate.[1] 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani[2]
IC50	LC50: 40 μg/mL (L. donovani)[2]
In Vitro	BOA induces oxidative stress in mung bean as indicated by increased generation of H2O2, enhanced LP and accumulation of endogenous PRO. It is accompanied by an upregulation of the activities of various scavenging enzymes—SODs, peroxidases, CATs and GR—in roots and leaves of mung bean in response to BOA exposure.[1] The LC50 values for BOA and pentamidine are 40 pg/ml and 39.8 pg/mi, respectively. BOA showed antileishmanial activity and compares well with pentamidine. [2]
激酶实验	For the BOA treatment, we followed the method used by Burgos and Talbert , wherein seeds germinated on a filter paper disc moistened with BOA and grow until the measurement of seedling length. Seeds of mung bean were surface sterilized with sodium hypochlorite (0.1%, w/v) followed by washing with distilled water three times. These were subjected to germination in 15 cm diameter Petri dishes lined with a Whatman no. 1 filter circle and moistened with 7 ml of respective BOA treatment solution or distilled water (control). The 7 ml of the 0.1, 0.5, 1.0, 2.5, and 5.0 mM BOA solution used cor_x005frespond to nearly 0.0946, 0.473, 0.946, 2.365, 4.73 mg ml–1 BOA, respectively. It was in the range similar to that used by Burgos and Talbert [13]. Twenty-five mung bean seeds were used in each Petri dish. Five replicates were maintained for each treatment in a completely randomized manner. All the Petri dishes were placed in a seed germinator maintained at 25 ± 2 °C, 75 ± 3% relative humidity and a 16 h:8 h light: dark photoperiod with a photosynthetic photon flux density of 150 μmol m–2 s–1. After 7 days, root and shoot length of emerged seedlings from each treatment were measured. Further, roots and leaves from each treatment were harvested and stored at –80 °C prior to enzyme extraction and other estimations.[1]
细胞实验	Promastigote para- sites in the stationary phase of growth (1 x io parasite/mi) were inoculated into culture tubes containing BHI-agar as solid part and HBSS as hquid part. To these tubes different concentrations (10 to 100 pg/mi, DMSO/PBS) of BOA and pentamidine were added, respectively. The inhibitory effect of BOA was compared with pentamidine which is known to be active against leishmaniasis, and with untreated control cultures. The whole operation was carried out aseptically in an ultraviolet chamber and the tubes were incubated for 5 days at 22 °C. The toxicity of DMSO was determined by adding different amounts of solvent (0.1 to 1.5%) to suspensions of promastigotes under the conditions described above. After five days the value of the non-toxic dilution was found to be 0.6% and growth inhibition (up to 15%) was observed between 0.6% and 1 %; therefore, higher concentrations of DMSO were never used. Antileishmanial activity of each of the com_x005fpounds was determined by counting the number of live parasites per field microscopically. The LC55 values were calculated by probit analysis and no mortallty was observed in mice when BOA was administered ((p.) in the doses ranging from 0.25—1 g/kg. The mice were kept under observation for one week.[2]
数据来源文献	[1] Batish D R , Singh H P , Setia N , et al. 2-Benzoxazolinone (BOA) induced oxidative stress, lipid peroxidation and changes in some antioxidant enzyme activities in mung bean (Phaseolus aureus).[J]. Plant Physiol Biochem, 2006, 44(11-12):819-827. [2]. Kapil A, et al. Leishmanicidal activity of 2-benzoxazolinone from Acanthus illicifolius in vitro. Planta Med. 1994 Apr;60(2):187-8.
规格	50mg 100mg 250mg
单位	瓶

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